Journal
FEBS LETTERS
Volume 486, Issue 2, Pages 117-120Publisher
WILEY
DOI: 10.1016/S0014-5793(00)02253-5
Keywords
scorpion toxin; K+-channel; Tityus cambridgei
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A new peptide, Tc1, containing only 23 amino acids closely packed by three disulfide bridges was isolated from the Amazonian scorpion Tityus cambridgei. It blocks reversibly the Shaker B K+-channels with a K-d of 65 nM and displaces binding of noxiustoxin to mouse brain synaptosome membranes. It is the shortest known peptide from scorpion venom that recognizes K+-channels and constitutes a new structural subfamily of toxin, classified as alphaKTx 13.1. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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