Journal
TETRAHEDRON LETTERS
Volume 41, Issue 50, Pages 9871-9874Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)01732-9
Keywords
solid phase synthesis; benzimidazole; SynPhase (TM) Lantern
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An improved solid phase synthesis of benzimidazoles is described. A polymer-bound o-nitroaniline was reacted with aldehydes in DMF in the presence of SnCl(2)(.)2H(2)O at 60 degreesC for three hours to give benzimidazoles in excellent purity and good yield after TFA cleavage. A library of 25 benzimidazoles was prepared using this 'one-pot' procedure. (C) 2000 Elsevier Science Ltd. All rights reserved.
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