Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 279, Issue 1, Pages 158-161Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.3924
Keywords
antisense oligonucleotides; animal model; transfection reagent; influenza A virus; viral RNA polymerase gene; gene therapy
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The antiviral effects of a 20-mer antisense phosphorothioate oligonucleotide, PB2-as, on influenza A virus infection in mice were examined and compared to those of PB2-as encapsulated with several cationic liposomes. Intravenous injection of PB2-as, as a complex with DMRIE-C, a cationic liposome, was most effective for prolonging the mean survival time in days (MSDs) and increasing the survival rates of mice infected with the influenza A virus. In addition, the liposomal PB2-as significantly inhibited viral growth in lung tissues. These results suggest that PBS-as encapsulated with DMRIE-C may be active against the influenza A virus infection through the inhibition of virus replication in the mouse lung. (C) 2000 Academic Press.
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