Journal
LANCET
Volume 356, Issue 9246, Pages 1985-1986Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(00)03315-8
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We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer, Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides. 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test. was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced GIN, indicating that E7-specific T-helper cells have a role in control of HPV.
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