Journal
BIOCONJUGATE CHEMISTRY
Volume 22, Issue 4, Pages 533-539Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc1005027
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Funding
- Sixth Framework Programme Marie Curie Host Fellowships for Early Stage Research Training [MEST-CT-2004-504018]
- Danish National Research Foundation
- presidium of Russian Academy of Sciences
- Dynasty Foundation
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Mixmer LNA/DNA fluorescent probes containing the 1-(phenylethynyl)pyrene fluorophore attached to 2'-arabino-uridine were synthesized and studied. The conjugates displayed significantly higher hybridization affinity to target DNA, increased fluorescence quantum yields of single-stranded oligonucleotides and their duplexes, and improved ability to form an interstrand excimer compared to analogous non-LNA probes.
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