Journal
APPLIED PHYSICS LETTERS
Volume 77, Issue 24, Pages 4049-4051Publisher
AMER INST PHYSICS
DOI: 10.1063/1.1332415
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We present a promising approach for the label-free characterization of genetic material. Time-resolved terahertz (THz) transmission analysis of polynucleotides demonstrate a strong dependence of the complex refractive index on the binding state (hybridized/denatured) of deoxyribonucleic acid (DNA) molecules. By monitoring THz transients, one can thus infer the binding state of oligo- and polynucleotides, and hence identify polynucleotides by detecting the binding of unknown polynucleotide DNA sequences to known probe molecules. A broadband experimental demonstration in a free-space configuration, as well as a discussion of the potential application for next generation gene chips is presented. (C) 2000 American Institute of Physics. [S0003-6951(00)01551-5].
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