Journal
CURRENT BIOLOGY
Volume 10, Issue 24, Pages R891-R895Publisher
CELL PRESS
DOI: 10.1016/S0960-9822(00)00845-9
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Funding
- NIGMS NIH HHS [GM-38542, R01 GM038542-12] Funding Source: Medline
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Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP2 and profilin, Network disassembly and debranching appears to be linked to actin bound ATP hydrolysis as filaments age.
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