Journal
ORGANIC LETTERS
Volume 2, Issue 25, Pages 4043-4046Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol006680s
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Funding
- NCI NIH HHS [CA24487, CA67786] Funding Source: Medline
- NIGMS NIH HHS [GM07273] Funding Source: Medline
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Organic extracts from cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antibiotic activity. Two endophytes CR200 (Cytospora sp,) and CR146 (Diaporthe sp,) were found to have potent antibiotic activity. Bioassay guided fractionation of the extracts from these fungi led to the identification of cytosporones D and E, antibacterial active trihydroxybenzene lactones, and three related but inactive metabolites, The five new octaketides were characterized using X-ray crystallography and NMR.
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