Journal
FEBS LETTERS
Volume 486, Issue 3, Pages 217-224Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02306-1
Keywords
inflammation; eosinophil; extracellular ATP; purinoceptor; oxygen radical
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Extracellular nucleotides elicit multiple responses in eosinophils but no information on expression of purinergic receptors in these cells is available so far. In the present study me show that human eosinophils express the following P2Y and P2X subtypes: P2Y(1), P2Y(2), P2Y(4), P2Y(6), P2Y(11), and P2X(1), P2X(4), P2X(7), whose stimulation results in intraccllular Ca2+ increase and production of large amounts of reactive oxygen intermediates. These events are stimulated or inhibited, respectively, by P2 receptor agonists or antagonists. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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