Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1529, Issue 1-3, Pages 142-154Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1388-1981(00)00144-X
Keywords
acyl-coenzyme A : choleslerol acytransferase; cholesterol; cholesterol ester; fatty acid; lipoprotein; atherosclerosis
Funding
- NHLBI NIH HHS [R01 HL057170, HL57170] Funding Source: Medline
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Cholesterol, the chief sterol found in vertebrates, exists both as a free sterol and as a component of cholesterol esters, which are-synthesized by acyl-CoA :cholesterol acyltransferase (ACAT) enzymes. Considerable knowledge concerning cholesterol ester metabolism has accumulated during the past century, However, rapid advances have occurred in the past 7 years since the cloning of an ACAT gene, including the discovery that two ACATs function in mammalian biology. A clearer picture of the functions of ACAT enzymes in cellular cholesterol metabolism and physiologic processes is now emerging. These insights may have-relevance for the development of ACAT inhibitors for treating hypercholesterolemia or atherosclerosis in humans. (C) 2000 Elsevier Science B.V. All rights reserved.
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