Journal
BIOCONJUGATE CHEMISTRY
Volume 21, Issue 12, Pages 2173-2177Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc100308p
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Funding
- MEST [2010-0019863, 2010-0019864]
- KIST
- Kyungwon University
- National Research Foundation of Korea [2010-0019863] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.
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