Journal
FEBS LETTERS
Volume 486, Issue 3, Pages 185-190Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02192-X
Keywords
antimicrobial peptide; defensin; mytilin; myticin; innate immunity; mussel; mollusc
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Recently, the existence and extended diversity of antimicrobial peptides has been revealed in two mussel species. These molecules are classified into four groups according to common features of their primary structure: defensins, mytilins, myticins and mytimycin. In Mytilus galloprovincialis, gene structure reveals synthesis as precursors in circulating hemocytes. Synthesised even in absence of challenge, the precursors mature and the peptides are stored in granules as active forms. The different peptides are engaged in the destruction of bacteria inside phagocytes, before being released into hemolymph to participate in systemic responses. Such involvement in anti-infectious responses is unique, and apparently more related to those of mammalian phagocytes than to those of insects. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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