Journal
JOURNAL OF IMMUNOLOGY
Volume 165, Issue 12, Pages 6833-6839Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.12.6833
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Funding
- NIAID NIH HHS [AI39031, AI42135, F32AI09629-02] Funding Source: Medline
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The duration of infection and the quantity of Ag presented in vivo are commonly assumed to influence, if not determine, the magnitude of T cell responses. Although the cessation of in vivo T cell expansion coincides with bacterial clearance in mice infected with Listeria monocytogenes, closer analysis suggests that control of T cell expansion and contraction is more complex. In this report, we show that the magnitude and kinetics of Ag-specific T cell responses are determined during the first day of bacterial infection. Expansion of Ag-specific T lymphocyte populations and generation of T cell memory are independent of the duration and severity of in vivo bacterial infection. Our studies indicate that the Ag-specific T cell response to L. monocytogenes is programmed before the peak of the innate inflammatory response and in vivo bacterial replication.
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