Journal
ANALYTICAL BIOCHEMISTRY
Volume 287, Issue 2, Pages 234-242Publisher
ACADEMIC PRESS INC
DOI: 10.1006/abio.2000.4856
Keywords
computational modeling; biosensor; displacement immunoassay
Ask authors/readers for more resources
Numerical modeling has been used to investigate the disparity in performance and sensitivity that has been reported for flow displacement immunosensors based on bead-packed columns, membranes, and capillary tubes. The simulations strongly suggest that the high surface areas in the porous media systems may actually be detrimental to sensor performance because of large numbers of free antibody binding sites. Since the free antibody sites are created during the wash step in which the baseline is established, wash protocols are critical in optimizing the sensitivity for a given displacement sensor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available