Journal
SCIENCE
Volume 290, Issue 5499, Pages 2110-2113Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5499.2110
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Funding
- NIDDK NIH HHS [R01 DK51562] Funding Source: Medline
- NIGMS NIH HHS [5F32GM20118-02] Funding Source: Medline
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Like most organisms, plants have endogenous biological clocks that coordinate internal events with the external environment. We used high-density oligonucleotide microarrays to examine gene expression in Arabidopsis and found that 6% of the more than 8000 genes on the array exhibited circadian changes in steady-state messenger RNA Levers. Clusters of circadian-regulated genes were found in pathways involved in plant responses to Light and other key metabolic pathways. Computational analysis of cycling genes allowed the identification of a highly conserved promoter motif that we found to be required for circadian control of gene expression. Our study presents a comprehensive view of the temporal compartmentalization of physiological pathways by the circadian clock in a eukaryote.
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