Journal
BIOCONJUGATE CHEMISTRY
Volume 21, Issue 12, Pages 2327-2331Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc100348q
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Funding
- National Science Foundation [MCB-0643832]
- NIH [1R21CA147912]
- Welch Foundation [C-1625]
- Army Medical Research and Material Command [BAA08-1]
- W. M. Keck Center for Interdisciplinary Bioscience Training of the Gulf Coast Consortia (NIH) [T32 EB009379]
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A class of reactive DNA circuits was adapted as erasable molecular imaging probes that allow fluorescent reporting complexes to be assembled and disassembled on a biological specimen. Circuit reactions are sequence-dependent and therefore facilitate multiplexed (multicolor) detection. Yet, the ability to disassemble reporting complexes also allows fluorophores to be removed and new circuit complexer to be used to label additional markers. Thus. these probes present opportunities to increase the total number of molecular targets that can be visualized on a biological sample by allowing multiple rounds of fluorescence microscopy to be performed.
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