Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 65, Issue 25, Pages 8774-8782Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo001356w
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A procedure is described for synthesizing appreciable quantities of both the tetradodecyloxy[6]-helicenebisquinone 1 (R = dodecyl), which exhibits unique optical properties but previously was difficult to prepare, and a variety of analogues. The synthesis starts from disodium 4,5rlihvdroxynaphthalene-2, 7-disulfonate, the commercially available dye-interme diate known as chromotropic acid. It gives enantiopure 1, with R = (i-Pr)(3)Si, whose silyl groups can be replaced by dodecyl and hexanoyl groups. The same procedure applied to disodium 4-hydroxynaphthalene-2,7disulfonate, also an inexpensive, commercially available chemical, works equally well to produce the corresponding molecules that have one fewer side chain. Key steps are the use of tosyl groups to protect phenols and of a method described seven years ago by Satoh, Itoh, Miura, and Nomura to transform the sulfonic acid functions to iodides. The structure of tetra-(1S)-camphanate 20, the ester of the reduction product of (-)-1 [R = (i-Pr)(3)Si], was analyzed by X-ray diffraction. It shows the absolute configurations and supports the presumed basis for the rule that the (1S)-camphanates of(P)-helicen-1-ols are more polar than their (M)-diastereomers.
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