Journal
STRUCTURE
Volume 8, Issue 12, Pages 1247-1257Publisher
CELL PRESS
DOI: 10.1016/S0969-2126(00)00533-5
Keywords
homoserine kinase; GHMP kinases; phosphate-binding loop; ATP binding
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Background: Homoserine kinase (HSK) catalyzes an important step in the threonine biosynthesis pathway. It belongs;to a large yet unique class of small metabolite kinases, the GHMP kinase superfamily. Members in the GHMP superfamily participate in several essential metabolic pathways, such as amino acid biosynthesis, galactose metabolism, and the mevalonate pathway.
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