Journal
NUCLEIC ACIDS RESEARCH
Volume 28, Issue 24, Pages 4846-4855Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/28.24.4846
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Funding
- NIAID NIH HHS [5T32AI07525, R01AI4576] Funding Source: Medline
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Blimp-1 is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Here we report the organization of the mouse Blimp-1 gene, an analysis of Blimp-1 homologs in different species, the characterization of Blimp-1 mRNA isoforms and initial studies on the transcription of Blimp-1, The murine Blimp-1 gene covers similar to 23 kb and contains eight exons, There are Blimp-1 homologs in species evolutionarily distant from mouse (Caenorhabditis elegans and Drosophila melanogaster) but no homolog was found in the unicellular yeast Saccharomyces cerevisiae, The three major Blimp-1 mRNA isoforms result from the use of different polyadenylation sites and do not encode different proteins, Run-on transcription analyses were used to show that the developmentally regulated expression of Blimp-1 mRNA in B cells is determined by transcription initiation. Multiple Blimp-1 transcription initiates sites were mapped near an initiator element and a region conferring basal promoter activity has been identified.
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