Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 192, Issue 12, Pages 1755-1762Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.192.12.1755
Keywords
MHC class I; posttranslational protein processing phosphopeptides; mass spectrometry; cytotoxic T lymphocytes
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Funding
- NCI NIH HHS [CA09109] Funding Source: Medline
- NIAID NIH HHS [AI20963, AI33993] Funding Source: Medline
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Posttranslational modification of peptide antigens has been shown to alter the ability of T cells to recognize major histocompatibility complex (MHC) class I-restricted peptides. However, the existence and origin of naturally processed phosphorylated peptides presented by MHC class I molecules have not been explored. By using mass spectrometry, significant numbers of naturally processed phosphorylated peptides were detected in association with several human MHC class I molecules. In addition, CD8(+) T cells could be generated that specifically recognized a phosphorylated epitope. Thus, phosphorylated peptides are part of the repertoire of antigens available for recognition by T cells in vivo.
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