Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 10, Issue 24, Pages 2787-2790Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00571-0
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A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI(2) agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 muM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats. (C) 2000 Elsevier Science Ltd. All rights reserved.
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