Journal
ONCOGENE
Volume 19, Issue 55, Pages 6533-6548Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204034
Keywords
Ets; transcription; target genes; expression arrays
Funding
- NCI NIH HHS [CA78582] Funding Source: Medline
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Ets is a family of transcription factors present in species ranging from sponges to human. All family members contain an approximately 85 amino acid DNA binding domain, designated the Ets domain. Ets proteins bind to specific purine-rich DNA sequences with a core motif of GGAA/T, and transcriptionally regulate a number of viral and cellular genes. Thus, Ets proteins are an important family of transcription factors that control the expression of genes that are critical for several biological processes, including cellular proliferation, differentiation, development, transformation, and apoptosis. Here, we tabulate genes that are regulated by Ets factors and describe past, present and future strategies for the identification and validation of Ets target genes. Through definition of authentic target genes, we will begin to understand the mechanisms by which Ets factors control normal and abnormal cellular processes.
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