Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 192, Issue 12, Pages 1841-1847Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.192.12.1841
Keywords
BTB-POZ protein; plasma cell; germinal center; retrovirus interleukins
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Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether arrest of terminal differentiation can be mediated by BCL-6, a transcriptional repressor that is expressed by germinal center B cells and is required for this phase of B cell development. We find that BCL-6 suppresses the differentiation of transformed and primary B cells to plasma cells by inhibiting the signal transducer and activator of transcription S-dependent expression of the major regulator of plasma cell development, the B lymphocyte-induced maturation protein (Blimp-1). This function of BCL-6 as a repressor of B lymphocyte differentiation may also underlie the association between chromosomal translocations of its gene and B cell lymphomas.
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