Journal
BIOCONJUGATE CHEMISTRY
Volume 20, Issue 6, Pages 1095-1099Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc900144m
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Funding
- National Natural Science Foundation of China [50733003, 20774089]
- Ministry of Sciences and Technology of the People's Republic of China [2006CB933300, 2009CB930300]
- Bairen Program of Chinese Academy of Sciences
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Aiming at development of a micellar nanoparticle system for intracellular drug release triggered by glutathione in tumor cells, a disulfide-linked biodegradable diblock copolymer of poly(E-caprolactone) and poly(ethyl ethylene phosphate) was synthesized. It formed biocompatible micelles loaded with doxorubicin in aqueous solution but detached the shell material under glutathione stimulus, resulting in rapid drug release with destruction of micellar structure. These glutathione-sensitive micelles also rapidly released the drug molecules intracellularly and led to enhanced growth inhibition to A549 tumor cells, suggesting that this nanoparticle system may have potential for improving drug delivery efficacy.
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