Journal
TETRAHEDRON
Volume 56, Issue 52, Pages 10175-10184Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(00)00862-0
Keywords
(-)-colchicine; Diels-Alder reacton; antitumor
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An enantioselective synthesis of (-)-colchicine, free from isocolchicine, is delineated and features tandem application of the intramolecular Diels-Alder reaction of acetylene-tethered oxazoles and the [4+3] cycloaddition of oxyallyls. This work underscores the synthetic utility of little explored oc-alkoxy substituted oxyallyls. (C) 2000 Elsevier Science Ltd. All rights reserved.
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