Journal
BRAIN RESEARCH
Volume 887, Issue 1, Pages 187-190Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)03042-0
Keywords
blood-brain barrier; brain edema; knock out mouse; microglia; plasminogen activator; urokinase
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Urokinase type plasminogen activator (uPA) may influence brain pathophysiology after injury. We studied disruption of the blood-brain barrier (BBB) and changes in the vasculature after a brain stab wound in uPA-deficient, uPA receptor-deficient, and PA inhibitor-1 (PAI-1) deficient mice. The extravasation of immunoglobulin was greater in PAI-1 deficient mice; less pronounced in uPA-deficient mice; similar to controls in uPA receptor-deficient mice. Vasculatures in the wound proliferated in PAI-1 deficient mice. Our study shows that uPA affects BBB disruption. PA enhances angiogenesis after brain injury. (C) 2000 Elsevier Science B.V. All rights reserved.
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