Journal
BIOCONJUGATE CHEMISTRY
Volume 19, Issue 2, Pages 391-402Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc700328s
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Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents. This review covers the bifunctional derivatives of DOTA, the solution and solid-phase synthesis of DOTA-peptide conjugates, their coordination and chelation chemistry, and the biomedical applications of various DOTA-peptide conjugate metal complexes.
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