Ligand substituent effects on asymmetric induction. Effect of structural variations of the DIOP ligand on the Rh-catalyzed asymmetric hydrogenation of enamides

[GRAPHICS] Substituent changes in the ligand (L*) backbone and the chelating phosphorus atoms of the classical DIOP ligand result in dramatic changes in the enantioselectivity of Rh+L*-catalyzed enamide hydrogenations.