Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
Volume 1543, Issue 2, Pages 434-455Publisher
ELSEVIER
DOI: 10.1016/S0167-4838(00)00234-X
Keywords
metabolic pathway engineering; ascorbic acid; 1,3-propanediol; isoprenoid; biocatalysis; aromatic
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Integration of metabolic pathway engineering and fermentation production technologies is necessary for the successful commercial production of chemicals. The 'toolbox' to do pathway engineering is ever expanding to enable mining of biodiversity, to maximize productivity, enhance carbon efficiency, improve product purity, expand product lines, and broaden markets. Functional genomics, proteomics, fluxomics, and physiomics are complementary to pathway engineering, and their successful applications are bound to multiply product turnover per cell, channel carbon efficiently, shrink the size of factories (i.e., reduce steel in the ground), and minimize product development cycle times to bring products to market. (C) 2000 Elsevier Science B.V. All rights reserved.
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