4.7 Article

Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 65, Issue 26, Pages 9120-9124

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo0012546

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Funding

  1. NCI NIH HHS [CA42056] Funding Source: Medline

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Convergent total syntheses of anhydrolycorinone, hippadine, and anhydrolycorinium chloride are detailed, enlisting sequential inverse electron demand Diels-Alder reactions of an unsymmetrical N-acyl-6-amino-1,2,4,5-tetrazine.

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