Journal
GENE
Volume 261, Issue 1, Pages 43-52Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1119(00)00490-X
Keywords
adaptive evolution; molecular evolution; multigene family; positive Darwinian selection; toxin; rapid divergence
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Animal toxins comprise a diverse array of proteins that have a variety of biochemical and pharmacological functions. A large number of animal toxins are encoded by multigene families. From studies of several toxin multigene families at the gene level the picture is emerging that most have been functionally diversified by gene duplication and adaptive evolution. The number of pharmacological activities in most toxin multigene families results from their adaptive evolution. The molecular evolution of animal toxins has been analysed in some multigene families, at both the intraspecies and interspecies levels. In most toxin multigene families, the rate of non-synonymous to synonymous substitutions (dN/dS) is higher than one. Thus natural selection has acted to diversify coding sequences and consequently the toxin functions. The selection pressure for the rapid adaptive evolution of animal toxins is the need for quick immobilization of the prey in classical predator and prey interactions. Currently available evidence for adaptive evolution in animal toxin multigene families will be considered in this review. (C) 2000 Elsevier Science B.V. All rights reserved.
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