Journal
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
Volume 495, Issue 2, Pages 146-151Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-0728(00)00409-5
Keywords
ITIES; ion transfer; lipophilicity; benzodiazepines; drugs behavior
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The transfer of benzodiazepine derivatives (diazepam, bromazepam, alprazolam, oxazepam, nitrazepam, clonazepam, chlordiazepoxide, flunitrazepam, midazolam and lorazepam) across the water [1,2-dichloroethane interface was studied using cyclic voltammetry. The partition coefficients of ionic species of benzodiazepines, log PXH+ were calculated from the transfer potentials measured at pH log PXH+ = log PXH+ - log P-X can be used in structure-activity correlations as it takes into account the effects of substituents on the main positions within the molecule. (C) 2001 Elsevier Science B.V. All rights reserved.
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