Journal
NEUROLOGY
Volume 56, Issue 1, Pages 127-129Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.56.1.127
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Funding
- NIA NIH HHS [AG05131, AG05681, AG10689, AG13991] Funding Source: Medline
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The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to I) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.
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