Journal
BIOCHIMIE
Volume 107, Issue -, Pages 28-32Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2014.10.011
Keywords
G protein-coupled membrane receptor; Rhodopsin; Membrane; Lipid; Cholesterol
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Funding
- Intramural Research Program of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
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The human genome encodes about 800 different G protein-coupled receptors (GPCR). They are key molecules in signal transduction pathways that transmit signals of a variety of ligands such as hormones and neurotransmitters to the cell interior. Upon ligand binding, the receptors undergo structural transitions that either enhance or inhibit transmission of a specific signal to the cell interior. Here we discuss results which indicate that transmission of such signals can be strongly modulated by the composition of the lipid matrix into which GPCR are imbedded. Experimental results have been obtained on rhodopsin, a prototype GPCR whose structure and function is representative for the great majority of GPCR in humans. The data shed light on the importance of curvature elastic stress in the lipid domain for function of GPCR. (C) Published by Elsevier B.V.
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