Journal
ONCOGENE
Volume 20, Issue 2, Pages 231-239Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204071
Keywords
v-myb oncogene; target gene; differential display; Pdcd4
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The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the ability of avian myeloblastosis virus (AMV) to transform mlyelomonocytic cells. v-Myb is thought to disrupt the differentiation of myelomonocytic cells by affecting the expression of specific target genes. To identify such genes we have analysed the gene expression in a myelomonocytic chicken cell Line that carries an estrogen inducible version of v-Myb by differential display, Here me describe the identification of the chicken homolog of the mouse Pdcd4 gene as a novel v-Myb target gene. Pdcd4 is also known as MA-3, TIS and H731 and has recently been shown to suppress the transformation of epidermal cells by tumor promoters. Our results provide the first evidence that v-Myb directly regulates the expression of a potential tumor suppressor gene.
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