Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 906, Issue 1-2, Pages 127-154Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(00)00955-9
Keywords
reviews; enantiomer separations; chiral stationary phases, LC; polysaccharides
Ask authors/readers for more resources
The direct chiral separation by chiral stationary phases (CSPs) is one of the most important techniques to analyze enantiomeric purity as well as to get enantiomerically pure material quickly. Among various types of CSPs, polysaccharide type CSPs are well known by their versatility and durability. They are not only effective under normal-phase conditions, but also under reversed-phase conditions. In order to get a good separation under the reversed-phase conditions, it is the key to choose an appropriate mobile phase. For example, a simple mixture of water/acetonitrile or water/methanol are sufficient for a neutral analyte, while it is necessary to use an acidic solution instead of water for an acidic analyte and a solution of a chaotropic salt (or a basic solution) for a basic analyte, respectively. The paper also presents lists of more than 350 separation examples that include 22 validated methods for drug analyses from serum, plasma or urine samples on polysaccharide type CSPs under reversed-phase conditions. (C) 2001 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available