Journal
FEBS LETTERS
Volume 488, Issue 1-2, Pages 34-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02401-7
Keywords
lysine; saccharopine; amino acid catabolism; neurotransmitter; brain
Ask authors/readers for more resources
Lysine has long been recognized as an essential amino acid for humans and the lack or low supply of this compound in the diet may lead to mental and physical handicaps. Since lysine is severely restricted in cereals, the most important staple food in the world, the understanding of ifs biological roles must be a major concern. Here we show that lysine is an important precursor for de novo synthesis of glutamate, the most significant excitatory neurotransmitter in the mammalian central nervous system. We also show that the synthesis of glutamate from lysine, which is carried out by the saccharopine pathway, is likely to take place in neurons. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available