Journal
TETRAHEDRON LETTERS
Volume 42, Issue 3, Pages 429-432Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)01984-5
Keywords
palladium and compounds; sulfur compounds; zinc and compounds; vitamins
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The Pd/C-catalyzed coupling reactions of thiol esters 1 with a zinc reagent 2 were accomplished in the presence of DMF leading to the polyfunctional ketones 3 in good yields under mild reaction conditions. The protocol was applied to the coupling reaction of a thiolactone 4c with a zinc reagent 2 to provide, after dehydration, a dehydrobiotin derivative 5c in 94% yield. (C) 2001 Elsevier Science Ltd. All rights reserved.
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