Journal
BIOCHIMIE
Volume 95, Issue 1, Pages 27-32Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2012.07.009
Keywords
ATP synthesis efficiency; Liver; Mitochondria; Nutrition; Undernutrition
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Funding
- Ligue Nationale contre le Cancer (comite 37,28), France
- Region Centre, France
- Canceropole Grand Ouest (axe Valorisation des produits de la mer en cancerologie) France
- French Ministere de l'Enseignement et de la Recherche
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Mitochondrial membranes are essential for the good functioning of the organelle. For instance, the inner mitochondrial membrane contains the oxidative phosphorylation system that permits ATP synthesis. Phospholipids environment and especially cardiolipin are crucial for the mitochondrial energy metabolism. Indeed, cardiolipin is known to provide essential structural and functional support to several proteins involved in oxidative phosphorylation. Alterations in cardiolipin structure, content and fatty acids composition have been associated with mitochondrial dysfunction in several physiopathological conditions and diseases. Cancer cachexia is a complex and dynamic process characterized by a negative energy balance induced by anorexia and hypermetabolism which leads to a drastic loss in body weight that aggravate prognosis of cancer patients. The underlying mechanisms of hypermetabolism are not fully understood. Whether the mitochondrial energy metabolism is altered during this disease and may participate to hypermetabolism is not clear. This mini-review focuses on cardiolipin especially its biosynthesis and remodeling pathways, its relation with mitochondrial energy metabolism and its possible implication in the cancer cachexia syndrome. (c) 2012 Elsevier Masson SAS. All rights reserved.
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