Journal
BRAIN RESEARCH
Volume 889, Issue 1-2, Pages 234-238Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)03048-1
Keywords
amyotrophic lateral sclerosis; Cu/Zn SOD; transgenic mice; calcineurin; calbindin
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A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneurons are affected by the neurodegenerative process; in contrast, calbindin-positive cells are selectively spared. The findings suggest that calcineurin plays a role as an accessory factor responsible for selective vulnerability in the neurodegenerative process of amyotrophic lateral sclerosis. (C) 2001 Elsevier Science B.V. All rights reserved.
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