Journal
NEUROSCIENCE LETTERS
Volume 297, Issue 3, Pages 187-190Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01697-9
Keywords
Alzheimer's disease; biological markers; cerebrospinal fluid; stroke; tau; hyperphosphorylated tau
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An increase in cerebrospinal fluid (CSF)-total-tau, and recently also in CSF-phospho-tau, has been found in Alzheimer's disease (AD). However, the mechanisms for these changes are not known. We examined longitudinal CSF samples from nine patients with acute stroke. As compared with baseline levels (day 0-1), CSF-total-tau showed an increase at day 2-3 (179%; P = 0.018), day 7-9 (257%; P = 0.003), and after 3 weeks (425%; P = 0.002) and returned to normal levels after 3-5 months (140%; NS). In contrast, there was no significant change in CSF-phospho-tau. These findings suggest that total tau and phospho-tau in CSF reflect different pathogenic processes in the brain; total-tau the deg ree of neuronal damage and phospho-tau the phosphorylation state of tau and thus possibly the formation of neurofibrillary tangles. (C) 2001 Published by Elsevier Science Ireland Ltd.
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