Journal
BIOCHIMIE
Volume 94, Issue 11, Pages 2280-2296Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2012.07.025
Keywords
DNA methylation; Screening tests; DNMT inhibitors; Epigenetics
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This review presents the different human DNA methyltransferases (DNMTs), their biological roles, their mechanisms of action and their role in cancer. The description of assays for detecting DNMT inhibitors (DNMTi) follows. The different known DNMTi are reported along with their advantages, drawbacks and clinical trials. A discussion on the features of the future DNMT inhibitors will conclude this review. (C) 2012 Elsevier Masson SAS. All rights reserved.
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