Journal
BIOCHIMIE
Volume 94, Issue 10, Pages 2097-2103Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2012.03.019
Keywords
Leptin; Cardiovascular; Metabolic syndrome; Heart failure; Obesity
Categories
Funding
- Heart & Stroke Foundation of Canada
- Canadian Institutes of Health Research
- Canadian Diabetes Association
- National Institutes of Health [R01-HL-73167, U01-HL-70525, U01-HL-087947]
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It is well established that individuals with the metabolic syndrome have a significantly increased risk of cardiovascular disease and much effort has been expended to elicit the underlying mechanisms. Various studies have proposed that excessive or deficient physiological effects mediated by leptin make an important contribution, yet many paradoxical observations often preclude a clear definition of the role of leptin. This review article will briefly discuss principal and most recent evidence on direct and indirect regulation of the cardiovascular system by leptin, focusing on cardiac structural and functional as well as vascular effects. (C) 2012 Elsevier Masson SAS. All rights reserved.
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