Journal
NEUROREPORT
Volume 12, Issue 1, Pages 11-15Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200101220-00010
Keywords
clozapine; haloperidol; negative symptom; phencyclidine (PCP); social behavior (SB)
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Phencyclidine (PCP) reduced social behavior (SB) in a dose- and time-dependent fashion. However, no such SE deficit was observed on repeated treatment with methamphetamine for 14 days. The SE deficit produced by treatment with PCP (10 mg/kg/day) for 14 days, which persisted for 28 days after withdrawal, was attenuated by clozapine (10 mg/kg/day) given for 7 days, whereas haloperidol for 7 days had no effect. Clozapine, but not haloperidol, alone at the same treatment dose increased SE in saline-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to test beneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which clozapine improves SE deficit. NeuroReport 12:11-15 (C) 2001 Lippincott Williams & Wilkins.
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