4.5 Article

Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 11, Issue 2, Pages 239-242

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00644-2

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Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro. (C) 2001 Elsevier Science Ltd. hll rights reserved.

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