Journal
BIOCHIMIE
Volume 94, Issue 7, Pages 1457-1463Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2012.03.015
Keywords
Cyclic phosphate; RNA ligation; RNA world; Self-organization; Self-replication
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Funding
- DFG [Mu1396/11-1]
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The RNA-world-theory is one possible explanation of how life on earth has evolved. In this context it is of high interest to search for molecular systems, capable of self-organization into structures with increasing complexity. We have engineered a simple catalytic system in which two short RNA molecules can catalyze their own ligation to form a larger RNA construct. The system is based on the hairpin ribozyme using a 2',3'-cyclophosphate as activated species for ligation. 2',3'-cyclic phosphates can be easily formed and occur in many natural systems, thus being superior candidates for activated building blocks in RNA world scenarios. (c) 2012 Elsevier Masson SAS. All rights reserved.
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