Journal
CANCER LETTERS
Volume 162, Issue 2, Pages 175-180Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(00)00645-5
Keywords
flavonoids; quercetin; glucoside; absorption; small intestine; sodium/glucose co-transporter-1
Categories
Ask authors/readers for more resources
Recently it has been postulated that flavonoid glucosides may be absorbed by the small intestine via the SGLT-1. Therefore, we applied an in vitro mucosal uptake method to investigate mucosal uptake of the non-metabolisable glucose analogue methyl-alpha -D-glucopyranoside (MDG) as influenced by quercetin-3-glucoside (isoquercitrin) and quercetin-4'-glucoside (spiraeosid). We found that both glucosides significantly inhibited SGLT-1 mediated MDG uptake whereas the aglycon quercetin or the quercetin-3-rhamnoglucoside (rutin) were ineffective. Calculated apparent kinetic parameters (K-m, V-max) of initial Na+-dependent MDG uptake by the jejunal mucosa indicate a competitive type of inhibition. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available