Journal
BIOCHIMIE
Volume 93, Issue 8, Pages 1351-1356Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2011.06.007
Keywords
G-quadruplexes; Natural polyamines; Dual-effect; Stabilization; Denaturation; Concentration
Categories
Ask authors/readers for more resources
Both G-quadruplexes and natural polyamines are intimately associated with tumor growth and proliferation. The effect of the natural polyamines on telomeric and some oncogenic G-quadruplexes including bcl-2, c-kit, and c-myc G-quadruplexes has been studied by using absorption, fluorescence, CD, and NMR methods. The results exhibited an interesting dual-effect depending on polyamines concentration. Polyamines promote and stabilize G-quadruplexes under a lower concentration (less than 1 mM) but denature G-quadruplexes under a higher concentration (more than 1 mM). Probably the electrostatic and hydrophobic effect of polyamines and the hydrogen-bonding interaction between guanines and polyamines were respectively responsible for the stabilizing and denaturing effect. (C) 2011 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available