Journal
TETRAHEDRON LETTERS
Volume 42, Issue 5, Pages 801-803Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)02115-8
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The C-15-C-28 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 12 linear steps with an overall yield of 14%. The methyldihydropyran ring of the side chain was efficiently prepared using ring-closing olefin metathesis chemistry and the 19,20-syn-diol was generated through the addition of a mixed vinyl zincate to a protected alpha -hydroxyaldehyde. (C) 2001 Published by Elsevier Science Ltd.
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