Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 98, Issue 3, Pages 1042-1046Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.031562998
Keywords
shear stress; endothelial cell; signal transduction
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Funding
- NHLBI NIH HHS [HL19454, R29 HL056707, HL64382, R01 HL064382, HL62747, HL56707, R01 HL056707, R01 HL019454] Funding Source: Medline
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The aim of this study is to elucidate the role of integrins in transducing fluid shear stress into intracellular signals in vascular endothelial cells, a fundamental process in vascular biology, We demonstrated that shear stress activates specific integrins in endothelial cells plated on substrates containing the cognate extracellular matrix (ECM) ligands. The shear stress-induced mechanotransduction, as manifested by integrin-Shc association, was abolished when new integrin-ECM ligand interactions were prevented by either blocking the integrin-binding sites of ECM ligands or conjugating the integrins to immobilized antibodies, Our results indicate that the dynamic formation of new connections between integrins and their specific ECM ligands is critical in relaying the signals induced by shear stress to intracellular pathways.
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